selinexor

A drug used to treat adults with certain types of diffuse large B-cell lymphoma that has come back or has not gotten better after treatment with at least two types of systemic therapy. It is also used with dexamethasone to treat adults with multiple myeloma that has come back or has not gotten better after treatment with at least four other anticancer therapies that included at least two proteasome inhibitors, at least two immunomodulating agents, and an anti-CD38 monoclonal antibody. It is also being studied in the treatment of other types of cancer. Selinexor blocks a protein called CRM1, which may help keep cancer cells from growing and may kill them. It is a type of small molecule inhibitor. Also called Xpovio.