PIK3CA gene

A gene that makes one of the proteins in an enzyme called PI3K. PI3K is involved in cell division, cell survival, and other important functions in a cell. It is also involved in the formation and growth of new blood vessels. Mutations (changes) in the PIK3CA gene may cause the PI3K enzyme to become overactive, which may cause cancer cells to grow. PIK3CA gene mutations have been found in many types of cancer, including cancers of the breast, lung, ovary, stomach, brain, colon, and rectum. They have also been found in some genetic conditions.