A substance being studied in the treatment of some types of cancer. Pevonedistat blocks an enzyme called NEDD8-activating enzyme (NAE), which is involved in cell division. Blocking this enzyme may help keep cancer cells from growing and may kill them. Pevonedistat is a type of NAE inhibitor and a type of targeted therapy.
( PEH-voh-NEH-dih-stat )
Source: NCI Dictionary of Cancer Terms
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