MUTYH-associated polyposis

A rare, inherited disorder in which multiple polyps (abnormal growths) form on the inner walls of the colon and rectum. People with MUTYH-associated polyposis usually develop fewer than 100 colon polyps, and polyps may also occur in the stomach and small intestine. People with MUTYH-associated polyposis have a high risk of developing colorectal cancer. They may also be at increased risk of developing cancers of the stomach, small intestine, ovary, endometrium, bladder, liver, thyroid, and skin. MUTYH-associated polyposis is caused by mutations (changes) in the MUTYH gene that are inherited in an autosomal recessive manner. It is a type of hereditary cancer syndrome. Also called MAP.