A condition marked by thickening of the outer layer of the skin, which is made of keratin (a tough, protective protein). It can result from normal use (corns, calluses), chronic inflammation (eczema), or genetic disorders (X-linked ichthyosis, ichthyosis vulgaris).
( HY-per-KAYR-uh-TOH-sis )
Source: NCI Dictionary of Cancer Terms
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