Hodgkin disease

A cancer of the immune system that is marked by the presence of a type of cell called the Reed-Sternberg cell. The two major types of Hodgkin disease are classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma. Signs and symptoms include painless, swollen lymph nodes, an enlarged spleen, fever, weight loss, fatigue, and night sweats. Also called Hodgkin lymphoma.