epidermodysplasia verruciformis

A rare, inherited disorder that makes people susceptible to chronic infection with certain types of human papillomavirus (HPV). It causes wart-like lesions or reddish-brown scaly patches to form most often on the skin of the face, neck, hands, arms, legs, feet, and trunk. Epidermodysplasia verruciformis usually appears at an early age and can get worse over time. People with this disorder have a high risk of developing nonmelanoma skin cancer at an early age, especially squamous cell skin cancer. Epidermodysplasia verruciformis is caused by mutations (changes) in the EVER1/TMC6 or EVER2/TMC8 genes.