entrectinib

A drug used in adults to treat non-small cell lung cancer that has spread to other parts of the body and is ROS1 positive. It is also used in adults and children aged 12 years or older to treat solid tumors that have spread to other parts of the body or cannot be removed by surgery and that got worse after other treatment or cannot be treated with other therapies. It is used in patients whose cancer has the NTRK gene fusion but does not have a drug resistance mutation (change) in certain TRK proteins. It is also being studied in the treatment of other types of cancer. Entrectinib blocks certain proteins involved in cell signaling and cell growth. These proteins may be found in a changed form or at high levels in some types of cancer cells. Blocking these proteins may help keep cancer cells from growing and may kill them. Entrectinib is a type of tyrosine kinase inhibitor and a type of targeted therapy. Also called Rozlytrek.